Amends the Controlled Substances Act to decrease (from five kilograms to one kilogram, and from 500 to 100 grams) the amounts of a mixture or substance containing a detectable amount of coca leaves, cocaine, ecgonine, or compounds thereof (cocaine powder) the manufacture, distribution, or possession of which is punishable by specified penalties under the Act. Directs the U.S. Sentencing Commission to promulgate or amend guidelines to reflect the amendment made by this Act.